The article discusses the attitude towards Christians, Muslims, and the “foreign sciences” based on one of the only extant polemical texts written in Early Judeo-Persian—a passage from an unpublished commentary on story of Ḥannah preserved in the National Library of Russia (RNL Yevr.-Arab. I 4608). In addition, the article attempts to define the relation of this commentary to the broader intellectual environment of the medieval Jewish world. A close examination of this passage reveals a possible connection to Karaite exegetical work written in Judeo-Arabic during the tenth century, particularly those of Yefet ben ʿEli. Therefore, the article may serve as a case study of intellectual contact and transmission of knowledge between different Jewish groups in the Islamicate world.